30대/초반
Facial flushing, paresthesia 증상으로 내원한 환자가 있어서 찾아 보았습니다.
약물 복용 이전부터 증상이 있었으므로 약물 이상 반응 같지는 않지만
그렇다고 30대 초반 남자 나이에 다른 질환은 있을 것 같지 않습니다.
(본원 혈액검사, chest PA 정상, 1년 전 타병원 chest CT, abdomen CT, blood test 정상)
Adverse Reactions
>10%:
Endocrine & metabolic: Increased serum triglycerides (25%)
Neuromuscular & skeletal: Back pain (children: 29%)
1% to 10%:
Ophthalmic: Conjunctivitis (4%), blepharitis (1%), chalazion (1%), hordeolum (1%)
Frequency not defined:
Cardiovascular: Cerebrovascular accident, chest pain, edema, flushing, palpitations, syncope, tachycardia, thrombosis
Central nervous system: Aggressive behavior, attempted suicide, depression, dizziness, drowsiness, emotional lability, fatigue, headache, insomnia, lethargy, malaise, nervousness, paresthesia, pseudotumor cerebri, psychosis, seizure, suicidal ideation, vasculitis (renal), violent behavior
Dermatologic: Acne fulminans, allergic skin reaction, alopecia, cheilitis, diaphoresis, eczema, eruptive xanthoma, facial erythema, hair disease, hirsutism, hyperpigmentation, hypopigmentation, nail disease, paronychia, pruritus, pyogenic granuloma, scaling of skin of feet, skin atrophy, skin photosensitivity, skin rash, sunburn (increased susceptibility), superficial peeling of palms, xeroderma
Endocrine & metabolic: Decreased HDL cholesterol, increased gamma-glutamyl transferase, increased lactate dehydrogenase, increased serum cholesterol, increased serum glucose, hyperuricemia, menstrual disease, weight loss
Gastrointestinal: Colitis, esophagitis, esophageal ulcer, gastrointestinal symptoms (nonspecific), gingival hemorrhage, gingivitis, inflammatory bowel disease, nausea, pancreatitis, xerostomia
Genitourinary: Genitourinary disease (nonspecific findings), hematuria, proteinuria, pyuria
Hematologic & oncologic: Anemia, bruise, lymphadenopathy, neutropenia, purpura, thrombocytopenia
Hepatic: Increased serum alkaline phosphatase, increased serum ALT, increased serum AST, hepatitis
Hypersensitivity: Anaphylaxis, hypersensitivity reaction
Infection: Herpes simplex infection (disseminated), infection
Neuromuscular & skeletal: Arthralgia, arthritis, bone disease, calcification of ligament, calcification of tendon, decreased bone mineral density, increased creatine phosphokinase, myalgia, premature epiphyseal closure, skeletal hyperostosis, tendonitis, weakness
Ophthalmic: Cataract, corneal opacity, keratitis, nocturnal amblyopia, optic neuritis, photophobia, vision color changes, visual disturbance
Otic: Auditory impairment, tinnitus
Renal: Glomerulonephritis
Respiratory: Bronchospasm, dry nose, epistaxis, respiratory tract infection, voice disorder, Wegener's granulomatosis
Miscellaneous: Wound healing impairment
<1%, postmarketing, and/or case reports: Agranulocytosis, contact lens intolerance, decreased visual acuity, dry eye syndrome, erythema multiforme, eye pain, eyelid disease (meibomian gland dysfunction/atrophy; Neudorfer 2012), myopia, rhabdomyolysis, Stevens-Johnson syndrome, toxic epidermal necrolysis
REF. UpToDate 2019.03.20
