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* Definitions:
1. Worrisome findings on smear: Leukemic blasts, leukoerythroblastosis
2. Persistent thrombocytosis: Platelets >450,000/microL confirmed on repeat CBC
3. Vasomotor symptoms: Erythromelalgia, flushing, pruritus
4. Constitutional symptoms: Fever, sweats, weight loss
5. Unusual thrombotic presentations (eg, unusual or multiple sites; <45 years old; unexplained, unprovoked, or recurrent thrombosis)
REF. UpToDate 2019.07.11
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