비염 치료를 위한 글루코코르티코이드 스프레이 [옴나리스, 아바미스, 나조크린 나잘스프레이]

비염 치료를 위한 글루코코르티코이드 스프레이

1. 옴나리스 나잘스프레이 - 시클레소니드 [SK케미칼]
2. 아바미스 나잘스프레이 - 플루티카손 푸로에이트 [GSK]
3. 나조크린 나잘스프레이 - 모메타손 [제일약품]

 

Glucocorticoid nasal sprays are the most effective single maintenance therapy for allergic rhinitis and cause few side effects at the recommended doses. These agents are particularly effective in the treatment of nasal congestion, which often does not respond to oral antihistamines. A limited number of comparative studies among different glucocorticoid nasal sprays have not demonstrated significant differences in efficacy nor is there any evidence that doses greater than the recommended maximum for each preparation provide additional benefit. Several glucocorticoid nasal sprays are available without a prescription.

 

 

Name	Common brand name(s) and strength	Generic available	Available without a prescription (OTC)	Usual adult dose per nostril	Lower age limit when used in children (years)*	Usual pediatric dose per nostril	Type of preparation (alcohol content)¶
Second-generation (systemic bioavailability <1% or undetectable)
Ciclesonide 옴나리스나잘스프레이	Omnaris (50 mcg/spray)	No	No	Two sprays once daily	2 years	2 to 11 years: One or two sprays once daily ≥12 years: Two sprays once daily	Aqueous suspension pump spray
	Zetonna (37 mcg/spray)	No	No	One spray once daily	12 years	≥12 years: One spray once daily	Pressurized aerosol spray (3.4% alcohol)
Fluticasone furoate 아바미스나잘스프레이	Flonase Sensimist (OTC) (27.5 mcg/spray)	No	Yes	Two sprays once daily	2 years	One or two sprays once daily; in children 2 to 11 years, start with one spray once daily	Aqueous suspension pump spray
Fluticasone propionate	Flonase Allergy Relief (OTC) (50 mcg/spray)	Yes	Yes	Two sprays once daily or one spray twice daily	4 years	4 to 11 years: One spray once daily ≥12 years: Two sprays once daily or one spray twice daily	Aqueous suspension pump spray (0.25% alcohol)
Mometasone 나조크린나잘스프레이	Nasonex 24HR Allergy (OTC) (50 mcg/spray)	Yes	Yes	Two sprays once daily	2 years	2 to 11 years: One spray once daily ≥12 years: Two sprays once daily	Aqueous suspension pump spray
First-generation (systemic bioavailability 10 to 50%)
Beclomethasone	Beconase AQ (42 mcg/spray)	No	No	One or two sprays twice daily	6 years	One or two sprays twice daily; in children 6 to 11 years, start with one spray twice daily	Aqueous suspension pump spray (0.25% alcohol)
	Pediatric: Qnasl Children's (40 mcg/spray) Adolescent/adult: Qnasl (80 mcg/spray)	No	No	Two sprays once daily using 80 mcg/spray product	4 years	4 to 11 years: One spray once daily using 40 mcg/spray product ≥12 years: Two sprays once daily using 80 mcg/spray product	Pressurized aerosol spray (8% alcohol)
Budesonide	Generic (formerly Rhinocort Allergy) (OTC) (32 mcg/spray)	Yes	Yes	One to two sprays once daily	6 years	One to two sprays once daily; in children 6 to 11 years, start with one spray twice daily	Aqueous suspension pump spray
Flunisolide	Generic (formerly Nasalide) (25 mcg/spray)	Yes	No	Two sprays two or three times daily (maximum two sprays four times daily)	6 years	6 to 14 years: One spray three times daily or two sprays twice daily ≥15 years: Two sprays two or three times daily (maximum two sprays four times daily)	Aqueous suspension pump spray (contains propylene glycol, a possible irritant)
Triamcinolone	GoodSense Nasal Allergy (OTC), Nasacort Allergy 24HR (OTC) (55 mcg/spray)	Yes	Yes	Two sprays once daily	2 years	2 to 5 years: One spray once daily ≥6 years: One to two sprays once daily; in children 6 to 11 years, start with one spray once daily	Aqueous suspension pump spray

Nasal sprays work best when they are administered properly and the medication remains in the nose rather than draining down the back of the throat. Note that the recommended techniques for the aqueous and aerosol sprays are different. If the nose is crusted or contains mucus, it should first be cleaned with a saline nasal spray prior to use of intranasal sprays. Some people find that holding the other nostril closed with a finger improves their ability to draw the spray into the upper nose.

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Once symptoms are controlled, the daily dose can be reduced to the lowest dose that maintains control.

Dosing and product descriptions are based upon products available in the United States and some other countries. Product descriptions in other countries may differ in some detail. Consult the drug monographs included within UpToDate and local product information for additional detail.

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OTC: over-the-counter (available without a prescription in the United States and some other countries).

* Lowest age use may differ from approved product labeling.

¶ Alcohol may contribute to dryness or irritation.

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Ref. UpToDate 2024.03.26