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Incidence rates of infective endocarditis following 2007 antimicrobial prophylaxis guidelines (September 2019)
Observational studies have sought to determine whether infective endocarditis (IE) rates have changed since publication of the 2007 American Heart Association (AHA) guideline for the prevention of IE that narrowed the indications for prophylaxis. A study of data from Ontario, Canada identified a decrease in antimicrobial prophylaxis and an increase in IE incidence after guideline publication. However, these findings do not establish causality, particularly since there was a three-year gap between guideline publication and increase in IE incidence. Given the available evidence we continue to recommend an approach to IE prophylaxis consistent with American College of Cardiology and AHA guidelines.
REF. UpToDate 2020.02.29
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