중국, 후베이성 우한시, 폐렴 집단 발생

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2002년 11월 SARS outbreak 발생

Guangdong Province in southern China

Severe acute respiratory syndrome – In November 2002, an outbreak of SARS started in Guangdong Province in southern China and spread worldwide, affecting more than 8000 persons. SARS was due to a novel coronavirus that jumped the species barrier from civet cats(사향고양이) to man. The case-fatality rate of the 2003 Hong Kong outbreak was 11 percent, but higher mortality was seen in older adults (≥60 years of age) and pregnant women. Superspreading events, which are outbreaks in which specific individuals are responsible for a disproportionately large number of transmission events, likely contributed to the SARS outbreak. UpToDate 2020.01.03

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In February 2003, the World Health Organization (WHO) reported about 300 cases of a rapidly progressive respiratory illness in the Guangdong Province of China with five deaths. Over the next month, similar cases were reported from Hong Kong, Vietnam, Singapore, and Canada. By the end of the worldwide outbreak in July 2003, a total of 8096 cases were reported, with 774 deaths and a case-fatality rate of 9.6 percent.

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Termed "severe acute respiratory syndrome" (SARS) by the WHO, initial efforts centered on tracking cases, determining an etiology, establishing a laboratory test for diagnosis, evaluating therapies, and implementing infection-control strategies to prevent further spread. The WHO spearheaded these efforts in collaboration with the United States Centers for Disease Control and Prevention (CDC) and health authorities from a number of countries, including particularly China, Hong Kong, Vietnam, Singapore, Thailand, and Canada.

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A novel coronavirus was detected in specimens from a number of the patients with SARS, and very quickly the virus was sequenced and fulfilled Koch's postulates.

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REF. UpToDate 2020.01.03