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심장내과/고혈압

Thiazide-Related antihypertensive diuretics : Chlorthalidone and indapamide

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Chlorthalidone and indapamide, commonly used thiazide-like diuretics, are significantly more potent antihypertensive agents than hydrochlorothiazide, a commonly used thiazide-type diuretic, at similar dose levels.

1. 클로르탈리돈(Chlorthalidone, 상품명: 하이그로톤정)

Oral: Initial: 12.5 to 25 mg once daily; titrate as needed based on patient response to 50 mg once daily; maximum: 100 mg/day; usual dosage range: 12.5 to 25 mg once daily (ACC/AHA [Whelton 2017])

2. 인다파미드 (Indapamide, 상품명: 후루덱스서방정)

Oral: Initial: 1.25 mg once daily; titrate as needed every 4 weeks up to 5 mg once daily. Usual dosage range: 1.25 to 2.5 mg once daily (ACC/AHA [Whelton 2017])

참고로 토르세마이드(torsemide)는 Antihypertensive; Diuretic, Loop에 속함, 고혈압에서는 primary agent가 아니며 alternative agent로 사용될 수 있음. 고혈압에서 흔하게 사용되는 thiazide-like diuretics는 chlorthalidone, indapamide이며 hydrochlorothiazide보다 더 강력한 고혈압 약제입니다.

REF. UpToDate 2019.07.24

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