Appropriate Dosage of Glimepiride when Switching from Glibenclamide/Gliclazide
Glimepiride 2 mg ~= gliclazide 40 mg 정도 ?
|
Drug |
Duration of biologic effect (hours) |
Usual daily dose (mg) |
Dosing per day |
|
Glipizide |
14 to 16 |
2.5 to 10 |
Once or divided* |
|
Glipizide XL |
24 |
5 to 10, up to 20 mg |
Once |
|
Gliclazide |
10 to 24 |
40 to 320 |
Once daily for doses <160 mg (doses of 160 mg and above should be taken in divided doses, morning and evening) |
|
Gliclazide MR |
>24 |
30 to 120 |
Once |
|
Glyburide (glibenclamide) |
20 to 24+ |
2.5 to 10 |
Once or divided* |
|
Glimepiride |
24+ |
2 to 4, up to 8 |
Once (can give 4 mg twice daily instead of 8 mg once daily) |
* Some patients may be effectively controlled on a once-daily regimen (2.5, 5, or 10 mg once daily) before the largest meal. Most have a better response with divided dosing (5 or 10 mg twice daily), depending on eating pattern.
glibenclamide 5.0mg → glimepiride 4mg or more
gliclazide 40mg → glimepiride 2mg or more
REF. UpToDate 2020.07.08